Before running the registry clean, make sure you back it up. Most registry cleaners have a back up option, but to be safe back it up yourself. Select a quality registry cleaner program. Run the program and review the list of files the registry say should delete. You can select the "fix all" option. Test your programs to make sure everything is working properly, worse case scenario if something doesn't work you have backed it up. You can find more information here: http://www.pcworld.com/article/153143/how_best_do_i_clean_my_registry.html
